KMID : 1039920210280020065
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Neonatal Medicine 2021 Volume.28 No. 2 p.65 ~ p.71
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Influence of Postconceptional Age on the Renal Biomarkers in Very-Low-Birth-Weight Infants
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Lee Ro-Sie
Shin So-Young Jung Won-Ho Park Jae-Hyun
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Abstract
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Purpose: We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in very-low-birth-weight (VLBW) infants.
Methods: Repeatedly measured samples for each infant were divided into four groups according to postnatal age: at birth (stage I), 3 to 7 days postnatally (stage II), 8 to 28 days postnatally (stage III), and >28 days postnatally (stage IV). The association between renal biomarkers and postconceptional age was assessed using Pearson¡¯s correlation coefficient, and the mean values of renal biomarkers in the four stages were compared using repeated-measures analysis of variance.
Results: For samples measured at birth, serum CysC (r=?0.358, P=0.032) and urinary NGAL/Cr ratio (r=?0.522, P=0.001) were negatively correlated with gestational age, whereas serum Cr (r=0.148, P=0.390) was not. In addition, for all samples measured, serum CysC (r=?0.209, P=0.012), urinary NGAL/Cr ratio (r=?0.536, P<0.001), and serum Cr (r=?0.311, P<0.001) were negatively correlated with postconceptional age. Compared with the mean values of the postnatal age-specific stages, serum CysC showed no significant differences in any of the four stages. However, the urinary NGAL/Cr ratio in stage IV was significantly different from those in stages I to III.
Conclusion: Although urinary NGAL/Cr ratio and serum CysC were negatively correlated with postconceptional age considering renal development, serum CysC showed no significant differences in any of the four postnatal age-specific stages. Urinary NGAL/Cr ratio at >28 days postnatally seems to be more affected by postconceptional age than serum CysC in VLBW infants.
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KEYWORD
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Cystatin C, Lipocalin-2, Infant, very low birth weight
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